Pinealon – 20MG per vial

Clinical Test Expectation Pinealon - Human Subjects : Anti-aging effect on brain and cardiovascular system. Assists bone calcification. Sleep regulation. Learning and memory formation. Aid Alzheimer’s disease / Parkinson’s disease. Potential therapeutic agent to treat depression. Reduces fatigue Strength - 20MG per vial

Introduction Pinealon is a short synthetic peptide composed of three amino acids Glu-Asp-Arg, also called the EDR peptide. Pinealon is known to impact the central nervous system leading to behavior modification, while also protecting the neurons and various other cell types from oxidative stress. The main advantage of this peptide is that it has the ability to penetrate through the blood brain barrier, cellular membrane, as well as the nuclear membrane. This is one of the reasons why it is able to interact directly with the DNA molecules.

Pinealon tripeptide is isolated from another chemical compound called Cortexin. Cortexin is a polypeptide that is synthesized from the bovine brain and was first introduced in 1999. Owing to its low molecular weight, Cortexin also possesses the ability to cross the blood brain barrier and produce stimulatory effects on the neurotransmitters in the brain. Pinealon has since been isolated and studied in elderly people to analyze its effects on the cerebral dysfunctions and ailments.

Neuroprotective and Anti-apoptotic Effects The neuroprotective (protecting neurons and neurotransmitters) and anti-apoptotic (cell death inhibition) effects of the Pinealon peptide are via the MAPK / ERK signaling pathway. ERK signaling cascade plays a vital role in the phosphorylation of the substrates leading to elevated neuron plasticity and increased cellular stress, leading to cellular apoptosis. Similarly, MAPK signaling leads to metabolic disorders and inflammatory reactions. Upon administration, Pinealon reduces the synthesis of reaction oxygen species (ROS) at the cell granular level. ROS acts as a messenger to MAPK and ERK signaling pathways, and the reduced synthesis thereby leads to reduction in the signaling reactions. This event in turn prevents cellular stress and consequent cell death.

Direct Interaction With the Cell Genome Studies on Pinealon have shown dose-dependent effects of the peptide. At lower doses, the peptide restricts the synthesis and subsequent accumulation of ROS and prevents cell death; while at higher doses, the peptide leads to a modulation of the cell cycle.This depicts that the peptide exerts antioxidant effects at lower concentrations while possessing the ability to directly interact with the cell genome and alter the cell cycle (4).

Benefits of the Pinealon peptide :

• Anti-aging effects
• Potential therapeutic agent to treat depression
• Potential therapeutic agent to treat brain disorders including:
  • Alzheimer’s disease
  • Parkinson’s disease
  • Memory enhancement
• Reduces fatigue
• Improves ability to concentrate
• Leads to behavioral modification

The main purpose of this study was to analyze the cellular and metabolic aspect of the synthetic tripeptides including Pinealon and a similar peptide called Vesugen. As part of this study, 32 volunteers (18 men and 12 women) between 41 and 83 years of age were enrolled in this study. All volunteers were suffering from poly-morbidity and organic brain syndrome. Both peptides demonstrated anabolic effects, improving the functioning of the central nervous system and other vital organs, which in turn slowed down the rate of aging. The peptides do not affect the degree of chromatin condensation, which demonstrates that the peptides are safe to use and do not adversely affect at the cellular levels.

Another separate study (6) has demonstrated that the Pinealon peptide acts on the muscle cells where it modulates the levels of irisin. Irisin is central to muscle cell protection and is mainly secreted during exercise. Irisin leads to the burning of excessive fat and is assumed to induce an elongation of telomere (DNA cap) as well.

Hence, by increasing irisin levels, Pinealon boosts protection of DNA telomeres and thereby helps fight the effects of aging.

Role in Prenatal Hyperhomocysteinemia Hyperhomocysteinemia is characterized by the excessive concentration of homocysteine (HC) amino acid in the blood, indicating extreme vitamin deficiency, which leads to increased risk of dementia.The main goal of this study (8) was to determine the effects of Pinealon on experimentally induced hyperhomocysteinemic pregnant female rats. The female rats were administered with methionine from their second trimester onwards which led to increased HC levels. The rat offspring from the healthy mice and the experimental mice were then used for this study.

Upon analysis, it was determined that the peptide did not reduce or inhibit the development of homocysteine in the offspring, however, there were some beneficial effects seen in the peptide administered rats as the rats demonstrated increased cognitive functions. This suggested that the peptide did not induce metabolism of homocysteine but led to reduced toxic effects of the compound.

Role in Depression Studies were conducted on the isolated brain cell cultures where the Pinealon peptide was administered in vitro. Upon analysis, it was seen that the peptide stimulated the levels of serotonin expression in the cell cultures.Through the molecular docking method, it was determined that the peptide regulated the synthesis of 5-typtophan hydroxylase enzyme that is involved in the synthesis of serotonin.Serotonin is a key hormone that helps stabilize the mood and overall well-being of an individual. This research establishes that the peptide may play a promising role in the treatment of depression.

Anti-apoptotic Effects Studies have shown that Pinealon peptide affects the levels of the caspase 3 enzyme. Caspase 3 enzyme is an initiator of cell apoptosis, or controlled cell death. When Pinealon peptide was administered in the experimental rat models suffering from an ischemic stroke, it modulated the levels of this enzyme, which thereby shut down the pathway of cellular death. This in turn reduced hypoxia effects during the stroke. Additionally, a separate research study showed that this effect of the peptide on the caspase 3 enzymes may also be beneficial in the treatment of the myocardial infarction.

Lastly, the benefits of suppressing the effects of caspase 3 enzyme were also seen in the skin cells. By reducing cellular apoptosis, the peptide stimulates cell proliferation in both young and aged people, hence leading to an increased regenerative process.

Role in Sleep Cycles Regulation and Other Effects on Pineal Gland As the name suggests, Pinealon peptide acts on the pineal gland of the body which is known to regulate the sleep cycle. The Pineal gland is located right at the center of the brain and is sensitive to light. Depending on the amount of light it is exposed to, it produces the melatonin hormone. In the dark environment, the pineal gland produces a higher amount of melatonin, which induces a greater amount of sleep.

Sleep cycle disturbances can either be natural due to increasing age or induced based on individual circumstances. Research has shown that when used in the state of insomnia or disturbed sleep cycle, Pinealon resets the pineal gland back to its optimal state and helps improve sleep, elevates the mood, and maintains blood pressure levels.

Besides sleep regulation, pineal gland also regulates cognitive function, bone calcification, and drug metabolism. All these abilities decline due to the shrinkage of the pineal gland with the increasing age. Hence, by preserving the pineal gland, Pinealon peptide demonstrates its geroprotective properties as it aids in maintaining a healthy well being at all ages.

Are There Any Negative Effects of Pinealon? The listed research studies have shown that the peptide possesses geroprotective properties and may potentially be used to treat ailments in aged people with no major side effects.

While research currently shows that the peptide can be deemed safe for use, it should be noted that there are some common side effects of peptides in general, which may also be applicable in this case:

• Pain, itchiness, and redness at the site of administration
• Nausea
• Vomiting
• Flu-like symptoms and headaches

Dosing Details You inject 2ml water into the vial of Pinealon from the water vial. 1 full syringe is 1ml. you then wait for the vial powder content to dissolve and once dissolved and clear you draw out 10 - 20 (1 - 2 units / 100 to 200 mcg) on the syringe 1 hour before activity. Inject it into the tummy under the skin into the fatty skin layer.

How long will a vial last ? A vial should last 10 days.

Clinical Test Expectation Adipotide - Human Subjects : Faster muscle mass growth, superior fat-burning power Strength - 5MG per vial

Introduction Adipotide is a synthetic peptide that possesses anti-obesity properties. this peptide particularly targets and destroys specific proteins that constitute the surface of blood vessels that support white fat (adipose) tissue hence interfering with the supply of blood to the fat cells and resulting in their adoptosis (reabsorption and metabolization). Adipotide was initially referred to as Prohibitin-TP01 (Prohibitin-Targeting Peptide 1). It is a peptidomimetic that was synthesized by American scientists as a potential therapeutic drug for obesity and its amino acid sequence is CKGGRAKDC-GG-D(KLAKLAK)2. Adipotide has a molecular formula of C111H204N36O28S2. Peptidomimetics are tiny protein like chains that imitate peptides. It is an experimental drug for weight loss. It was developed in a way that enables it to bind to two receptors, prohibitin and ANXA2 which are found in blood vessels that support white adipose tissue. In rat and monkey based experiments, Adipotide has been shown to bring about rapid weight loss in both mice and rhesus monkeys. In general, Adipotide has been observed to bring about weight loss by reducing fat tissue especially in the abdominal region), rapid metabolic changes, and decreased food intake.

Dosing Details ADIPOTIDE – Week 1 : You inject 2ml water into the vial of Adipotide from the water vial. 1 full syringe is 1ml. You then wait for the vial powder content to dissolve ON ITS OWN. DO NOT SHAKE THE VIAL TO MIX POWDER. Once dissolved and clear in colour you draw out 15 (one and a half units) on the syringe each morning before breakfast and inject it into the tummy under the skin into the fatty skin layer. A vial should last 14 days. ADIPOTIDE – Week 2 to 4 :You inject 2ml water into the vial of Adipotide from the water vial. 1 full syringe is 1ml. You then wait for the vial powder content to dissolve ON ITS OWN. DO NOT SHAKE THE VIAL TO MIX POWDER. Once dissolved and clear in colour you draw out 30 (3 units) on the syringe each morning before breakfast and inject it into the tummy under the skin into the fatty skin layer. A vial should last 7 days. Alternative Salon usage : You inject 4ml water into the vial of Adipotide from the water vial. 1 full syringe is 1ml. You then wait for the vial powder content to dissolve ON ITS OWN. DO NOT SHAKE THE VIAL TO MIX POWDER. Once dissolved and clear in colour you draw out 60 (6 units) on the syringe and inject 15 (one quarter of drawn amount) into each corner of the areas you want to be affected, for client. A vial should last 7 days.

How long will a vial last ? A vial should last 7 to 14 days

Clinical Test Expectation Hexarelin - Human Subjects :Lean muscle growth. Rapid fat loss. Increased tendon and ligament strength. Enhanced flexibility. Better recovery. Cardiovascular aid Strength - 2MG per vial

Introduction Hexarelin is used to stimulate natural growth hormone production, promoting lean muscle growth, rapid fat loss, increased tendon and ligament strength, enhanced flexibility, and better recovery from injuries and training sessions. Hexarelin, a synthetic growth hormone-releasing peptide, can bind to and activate the growth hormone secretagogue receptor (GHSR) in the brain similar to its natural analog ghrelin. However, the peripheral distribution of GHSR in the heart and blood vessels suggests that hexarelin might have direct cardiovascular actions beyond growth hormone release and neuroendocrine effects. Furthermore, the non-GHSR CD36 had been demonstrated to be a specific cardiac receptor for hexarelin and to mediate its cardioprotective effects. When compared with ghrelin, hexarelin is chemically more stable and functionally more potent. Therefore, it may be a promising therapeutic agent for some cardiovascular conditions.

Dosing Details You inject 2ml water into the vial of Hexarelin from the water vial. 1 full syringe is 1ml. You then wait for the vial powder content to dissolve ON ITS OWN. DO NOT SHAKE THE VIAL TO MIX POWDER. Once dissolved and clear in colour you draw out 20 (2 units) on the syringe each night before bed and inject it into the tummy under the skin into the fatty skin layer.

How long will a vial last ? A vial should last 7 days.

Clinical Test Expectation GHK-cu - Human Subjects : Wound healing and antiaging skin care ++. Antioxidant and Anti-Inflammatory Properties. Stimulates Blood Vessel Growth. Increases Neurotrophins. Gene Regulator. Reverse Gene Silencing Strength - 100MG per vial

Introduction The human peptide GHK-cu (glycyl-l-histidyl-l-lysine) has multiple biological actions, all of which, according to our current knowledge, appear to be health positive. It stimulates blood vessel and nerve outgrowth, increases collagen, elastin, and glycosaminoglycan synthesis, as well as supports the function of dermal fibroblasts. GHK’s ability to improve tissue repair has been demonstrated for skin, lung connective tissue, boney tissue, liver, and stomach lining. GHK has also been found to possess powerful cell protective actions, such as multiple anti-cancer activities and anti-inflammatory actions, lung protection and restoration of chronic obstructive pulmonary disease (COPD) fibroblasts, suppression of molecules thought to accelerate the diseases of aging such as NFκB, anti-anxiety, anti-pain and anti-aggression activities, DNA repair, and activation of cell cleansing via the proteasome system. Recent genetic data may explain such diverse protective and healing actions of one molecule, revealing multiple biochemical pathways regulated by GHK.

Dosing Details You inject 2ml water into the vial of GHK cu from the water vial. 1 full syringe is 1ml. You then wait for the vial powder content to dissolve ON ITS OWN. DO NOT SHAKE THE VIAL TO MIX POWDER. Once dissolved and clear blue in colour you draw out 20 (2 units) on the syringe each morning before breakfast and inject it into the tummy under the skin into the fatty skin layer.

How long will a vial last ? A vial should last 10 days.

Clinical Test Expectation - Human Subjects : Reduces body fat. Stimulates lipolysis. Triggers fat release from obese fat cells Strength - 2MG per vial

Introduction AOD 9604 is a modified form of Growth Hormone, which is a 191 amino acid peptide. The last 15 amino acids (176-191) of the Growth Hormone polypeptide have been reproduced as a specific peptide and is called GH Frag 176-191 or AOD 9604. This peptide is used for burning fat and medically assisted weight loss, and it has other benefits as well. Gland stimulated is the Pituitary Gland.

While it's best known as a fat-burning peptide, there are plenty of other benefits to using AOD-9604. Here are some to note:

• Reduces body fat
• Triggers fat release from obese fat cells predominantly more than lean ones
• Mimics the way natural growth hormone regulates fat metabolism
• No adverse effects on blood sugar or growth
• Stimulates lipolysis
• Inhibits lipogenesis (the transformation of non-fatty foods into body fat)
• Favorable cartilage repair and regenerative properties, especially when paired with peptide BPC 157

AOD-9604, also known as Tyr-hGH Frag 176-191, has been proven to have a strong fat-burning capacity without creating a desire to overeat. It doesn't affect blood sugar or tissue growth. (Heffernan 2001 Heffernan 2001, Ng 2000).

AOD-9604 activates degradation and fat burning (oxidation) by a method that doesn't use the hGH receptor; it has its own mechanism of action independent of hGH. Laboratory studies on rodents, pigs, dogs & humans have identified the AOD-9604 mechanism which triggers fat release from the obese fat cells predominantly and works to reduce the accumulation of new fat in fat cells as well as increase fat burning. What is extraordinary about the AOD-9604 is its ability to reduce abdominal fat stores.

The second most potent fat loss peptide is CJC-1295 since it leads to an increase in overall GH levels in the body (the opposite of what happens typically as individuals age).

This explains one of the reasons people have tended to gain fat as they get older. If your only goal is fat loss, it's usually best to avoid using products GHRP (GHRP-6, GHRP-2 or GHRH’s) because they may give you the side effects of increased hunger and raised cortisol. AOD-9604 does not increase hunger or raise cortisol.

Dosing Details You inject 2ml water into the vial of AOD from the water vial. 1 full syringe is 1ml. You then wait for the vial powder content to dissolve ON ITS OWN. DO NOT SHAKE THE VIAL TO MIX POWDER. Once dissolved and clear in colour you draw out 30 (3 units) on the syringe each night before bed and inject it into the tummy under the skin into the fatty skin layer.

How long will a vial last ? A vial should last 7 days.

Clinical Test Expectation Melanotan II - Human Subjects : Tanning the skin. Producing erections in men with ED (erectile dysfunction), when given as a shot under the skin Strength - 10MG per vial

Introduction Melanotan-II is a lab-made chemical that is similar to a hormone found in people. Be careful not to confuse melanotan-II with melatonin. Melanotan-II is given as a shot to produce erections in men with ED (erectile dysfunction), tan the skin, and prevent skin cancers caused by sun exposure.

How long will a vial last ? A vial should last 15-20 days