| Content | Clinical Test Expectation Oxytocin Nasal Spray – Human Subjects : Regulate reproduction functions. Effects on emotion – Psychological stability. Build connections. Affects mood. Builds trust. Lowers anxiety. Lowers stress
Strength – 2mg per vial
Dosing Details
Inject 1 ml water into the vial of Oxytocin Nasal Spray from the vial of water. 1 ml is a full syringe. Do not shake the vial to mix powder and water, allow this to mix on its own till clear in colour, should take around 5 minutes. Draw out all the contents of the vial once mixed and clear in colour and inject into the nasal sprayer bottle. Then inject the balance of all the water in the 2 water vials (5ml each) or 1 vial of water (10ml) into the nasal bottle. So in total there will be 10ml water in the nasal bottle and the contents of the vial. Spray 2 times a day per nostril and increase to 4 times a day per nostril after week 1.
Although this item is a different version of the injectable peptide, the action and mechanisms of action are the same. For more information on the action and mechanisms of action for this product please click here : Oxytocin (Love Hormone) – 2MG per vial
Do I pick the nasal or the injectable ? Which is better ??
Biologically they are the same in terms of result just that they differ in terms of method of absorption. The selection of one or the other is normally based on preference. Also some people do report one or the other to have worked better for them. We are not sure what causes this variance as they are both the same in terms of action and strength. It is only the absorption method that varies by design respectively | Clinical Test Expectation Pinealon - Human Subjects : Anti-aging effect on brain and cardiovascular system. Assists bone calcification. Sleep regulation. Learning and memory formation. Aid Alzheimer’s disease / Parkinson’s disease. Potential therapeutic agent to treat depression. Reduces fatigue
Strength - 20MG per vial
Introduction
Pinealon is a short synthetic peptide composed of three amino acids Glu-Asp-Arg, also called the EDR peptide. Pinealon is known to impact the central nervous system leading to behavior modification, while also protecting the neurons and various other cell types from oxidative stress. The main advantage of this peptide is that it has the ability to penetrate through the blood brain barrier, cellular membrane, as well as the nuclear membrane. This is one of the reasons why it is able to interact directly with the DNA molecules.
Pinealon tripeptide is isolated from another chemical compound called Cortexin. Cortexin is a polypeptide that is synthesized from the bovine brain and was first introduced in 1999. Owing to its low molecular weight, Cortexin also possesses the ability to cross the blood brain barrier and produce stimulatory effects on the neurotransmitters in the brain. Pinealon has since been isolated and studied in elderly people to analyze its effects on the cerebral dysfunctions and ailments.
Neuroprotective and Anti-apoptotic Effects
The neuroprotective (protecting neurons and neurotransmitters) and anti-apoptotic (cell death inhibition) effects of the Pinealon peptide are via the MAPK / ERK signaling pathway. ERK signaling cascade plays a vital role in the phosphorylation of the substrates leading to elevated neuron plasticity and increased cellular stress, leading to cellular apoptosis. Similarly, MAPK signaling leads to metabolic disorders and inflammatory reactions. Upon administration, Pinealon reduces the synthesis of reaction oxygen species (ROS) at the cell granular level. ROS acts as a messenger to MAPK and ERK signaling pathways, and the reduced synthesis thereby leads to reduction in the signaling reactions. This event in turn prevents cellular stress and consequent cell death.
Direct Interaction With the Cell Genome
Studies on Pinealon have shown dose-dependent effects of the peptide. At lower doses, the peptide restricts the synthesis and subsequent accumulation of ROS and prevents cell death; while at higher doses, the peptide leads to a modulation of the cell cycle.This depicts that the peptide exerts antioxidant effects at lower concentrations while possessing the ability to directly interact with the cell genome and alter the cell cycle (4).
Benefits of the Pinealon peptide :
- Anti-aging effects
- Potential therapeutic agent to treat depression
- Potential therapeutic agent to treat brain disorders including:
- Alzheimer’s disease
- Parkinson’s disease
- Memory enhancement
- Reduces fatigue
- Improves ability to concentrate
- Leads to behavioral modification
The main purpose of this study was to analyze the cellular and metabolic aspect of the synthetic tripeptides including Pinealon and a similar peptide called Vesugen. As part of this study, 32 volunteers (18 men and 12 women) between 41 and 83 years of age were enrolled in this study. All volunteers were suffering from poly-morbidity and organic brain syndrome. Both peptides demonstrated anabolic effects, improving the functioning of the central nervous system and other vital organs, which in turn slowed down the rate of aging. The peptides do not affect the degree of chromatin condensation, which demonstrates that the peptides are safe to use and do not adversely affect at the cellular levels.
Another separate study (6) has demonstrated that the Pinealon peptide acts on the muscle cells where it modulates the levels of irisin. Irisin is central to muscle cell protection and is mainly secreted during exercise. Irisin leads to the burning of excessive fat and is assumed to induce an elongation of telomere (DNA cap) as well.
Hence, by increasing irisin levels, Pinealon boosts protection of DNA telomeres and thereby helps fight the effects of aging.
Role in Prenatal Hyperhomocysteinemia
Hyperhomocysteinemia is characterized by the excessive concentration of homocysteine (HC) amino acid in the blood, indicating extreme vitamin deficiency, which leads to increased risk of dementia.The main goal of this study (8) was to determine the effects of Pinealon on experimentally induced hyperhomocysteinemic pregnant female rats. The female rats were administered with methionine from their second trimester onwards which led to increased HC levels. The rat offspring from the healthy mice and the experimental mice were then used for this study.
Upon analysis, it was determined that the peptide did not reduce or inhibit the development of homocysteine in the offspring, however, there were some beneficial effects seen in the peptide administered rats as the rats demonstrated increased cognitive functions. This suggested that the peptide did not induce metabolism of homocysteine but led to reduced toxic effects of the compound.
Role in Depression
Studies were conducted on the isolated brain cell cultures where the Pinealon peptide was administered in vitro. Upon analysis, it was seen that the peptide stimulated the levels of serotonin expression in the cell cultures.Through the molecular docking method, it was determined that the peptide regulated the synthesis of 5-typtophan hydroxylase enzyme that is involved in the synthesis of serotonin.Serotonin is a key hormone that helps stabilize the mood and overall well-being of an individual. This research establishes that the peptide may play a promising role in the treatment of depression.
Anti-apoptotic Effects
Studies have shown that Pinealon peptide affects the levels of the caspase 3 enzyme. Caspase 3 enzyme is an initiator of cell apoptosis, or controlled cell death. When Pinealon peptide was administered in the experimental rat models suffering from an ischemic stroke, it modulated the levels of this enzyme, which thereby shut down the pathway of cellular death. This in turn reduced hypoxia effects during the stroke. Additionally, a separate research study showed that this effect of the peptide on the caspase 3 enzymes may also be beneficial in the treatment of the myocardial infarction.
Lastly, the benefits of suppressing the effects of caspase 3 enzyme were also seen in the skin cells. By reducing cellular apoptosis, the peptide stimulates cell proliferation in both young and aged people, hence leading to an increased regenerative process.
Role in Sleep Cycles Regulation and Other Effects on Pineal Gland
As the name suggests, Pinealon peptide acts on the pineal gland of the body which is known to regulate the sleep cycle. The Pineal gland is located right at the center of the brain and is sensitive to light. Depending on the amount of light it is exposed to, it produces the melatonin hormone. In the dark environment, the pineal gland produces a higher amount of melatonin, which induces a greater amount of sleep.
Sleep cycle disturbances can either be natural due to increasing age or induced based on individual circumstances. Research has shown that when used in the state of insomnia or disturbed sleep cycle, Pinealon resets the pineal gland back to its optimal state and helps improve sleep, elevates the mood, and maintains blood pressure levels.
Besides sleep regulation, pineal gland also regulates cognitive function, bone calcification, and drug metabolism. All these abilities decline due to the shrinkage of the pineal gland with the increasing age. Hence, by preserving the pineal gland, Pinealon peptide demonstrates its geroprotective properties as it aids in maintaining a healthy well being at all ages.
Are There Any Negative Effects of Pinealon?
The listed research studies have shown that the peptide possesses geroprotective properties and may potentially be used to treat ailments in aged people with no major side effects.
While research currently shows that the peptide can be deemed safe for use, it should be noted that there are some common side effects of peptides in general, which may also be applicable in this case:
- Pain, itchiness, and redness at the site of administration
- Nausea
- Vomiting
- Flu-like symptoms and headaches
Dosing Details
You inject 2ml water into the vial of Pinealon from the water vial. 1 full syringe is 1ml. you then wait for the vial powder content to dissolve and once dissolved and clear you draw out 10 - 20 (1 - 2 units / 100 to 200 mcg) on the syringe 1 hour before activity. Inject it into the tummy under the skin into the fatty skin layer.
How long will a vial last ?
A vial should last 10 days. | Clinical Test Expectation Gonadorelin Nasal Spray – Human Subjects : In males – Delayed puberty. Infertility in males caused by pituitary or hypothalamus problems. In females – cause ovulation (release of an egg from the ovary) in women who do not have regular ovulation and menstrual periods
Strength – 5MG per vial
Dosing Details
Inject 1 ml water into the vial of Gonadorelin Nasal Spray from the vial of water. 1 ml is a full syringe. Draw out all the contents of the vial once mixed and clear in colour and inject into the nasal bottle. Then inject the balance of all the water in the 2 water vials 5ml each / 1 vial 10ml into the nasal bottle. So in total there will be 10ml water in the nasal bottle and the contents of the vial. Spray 2 times per nostril at night
Although this item is a different version of the injectable peptide, the action and mechanisms of action are the same. For more information on the action and mechanisms of action for this product please click here : Gonadorelin (Gonadotropin-releasing hormone (GnRH)) – 5mg per vial
Do I pick the nasal or the injectable ? Which is better ??
Biologically they are the same in terms of result just that they differ in terms of method of absorption. The selection of one or the other is normally based on preference. Also some people do report one or the other to have worked better for them. We are not sure what causes this variance as they are both the same in terms of action and strength. It is only the absorption method that varies by design respectively | Clinical Test Expectation DSIP - Human Subjects : Help induce better sleep. Relieves emotional and psychological responses to stress
Strength - 2MG per vial
Introduction
The DSIP or the Delta sleep-inducing Peptide is a somnogeneric nonapeptide that impacts the neuromodulation. It is typically found in the brain and passes by the blood barriers quite quickly. Studies have shown that DSIP and as well as its analogs are classified as peptide neuromodulators. Studies have also shown that DSIP has exhibited a stress-protective action that helps decrease stress metabolic disorders for humans and animals.
It is believed that the Delta Sleep-Inducing Peptide works in such a way that it modulates the activity of GABAergic gluta and other neuronal systems too.
DSIP in summary :
- Help induce better sleep
- And relieve emotional and psychological responses to stress
Although, it is not recommended to give out DSIP just before going to bed. The dose should be given during the day to help improve sleep the next night and as well as several days to come.
But you must remember that DSIP only works for short-term benefits and not for long-term management for insomnia.
Dosing Details
You inject 2ml water into the vial of DSIP from the water vial. 1 full syringe is 1ml. You then wait for the vial powder content to dissolve ON ITS OWN. DO NOT SHAKE THE VIAL TO MIX POWDER. Once dissolved and clear in colour you draw out 10 – 20 (1 to 2 units) as tolerance increases , on the syringe each night before bed and inject it into the tummy under the skin into the fatty skin layer. A vial should last 10-20 days depending on dose used.
How long will a vial last ?
A vial should last 10-20 days. | Clinical Test Expectation Sermorelin Nasal Spray – Human Subjects : Miracle Skin tone improvements. Improves sleep. Strengthen immune system, Anti Aging. General well-being. Lean body mass. Helps insulin sensitivity. Helps Libido
Strength – 2MG per vial
Dosing Details
Inject 1 ml water into the vial of Sermorelin Nasal Spray from the vial of water. 1 ml is a full syringe. Draw out all the contents of the vial once mixed and clear in colour and inject into the nasal bottle. Then inject the balance of all the water in the 2 water vials 5ml each / 1 vial 10ml into the nasal bottle. So in total there will be 10ml water in the nasal bottle and the contents of the vial. Spray 2 times per nostril at night before bed.
Although this item is a different version of the injectable peptide, the action and mechanisms of action are the same. For more information on the action and mechanisms of action for this product please click here : Sermorelin – 2MG per vial
Do I pick the nasal or the injectable ? Which is better ??
Biologically they are the same in terms of result just that they differ in terms of method of absorption. The selection of one or the other is normally based on preference. Also some people do report one or the other to have worked better for them. We are not sure what causes this variance as they are both the same in terms of action and strength. It is only the absorption method that varies by design respectively | Clinical Test Expectation Hexarelin Nasal Spray – Human Subjects : Lean muscle growth. Rapid fat loss. Increased tendon and ligament strength. Enhanced flexibility. Better recovery. Cardiovascular aid
Strength – 2MG per vial
Dosing Details
Inject 1 ml water into the vial of Hexarelin Nasal Spray from the vial of water. 1 ml is a full syringe. Draw out all the contents of the vial once mixed and clear in colour and inject into the nasal bottle. Then inject the balance of all the water in the 2 water vials 5ml each / 1 vial 10ml into the nasal bottle. So in total there will be 10ml water in the nasal bottle and the contents of the vial. Spray 2 times per nostril at night
Although this item is a different version of the injectable peptide, the action and mechanisms of action are the same. For more information on the action and mechanisms of action for this product please click here : Hexarelin (HEX) – 2MG per vial
Do I pick the nasal or the injectable ? Which is better ??
Biologically they are the same in terms of result just that they differ in terms of method of absorption. The selection of one or the other is normally based on preference. Also some people do report one or the other to have worked better for them. We are not sure what causes this variance as they are both the same in terms of action and strength. It is only the absorption method that varies by design respectively |
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